The BBB can resist leakage during systemic inflammation, especially at low levels, which is partly attributed to its robust efflux system, which plays a crucial role in maintaining the brains protected environment [109, 110]
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ALCAR and KET also activated brainstem nuclei (locus coeruleus, diagonal band, and raphe nuclei) which send aminergic projections to cortical areas and spinal dorsal horns that are involved in pain and mood control ( Altogether, the findings indicate that non-selective, clinical glutamate modulators such as ALCAR and KET can still provide therapeutic benefits and generate hypotheses on glutamate drug actions in neuropsychiatric conditions
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